Five new terpenoids and their anti-injury activity from Zingiberis Rhizoma

Three new sesquiterpenoids, gingerterpenes B–D (1–3), two new diterpenoids, gingerterpenes E–F (4–5), and two known sesquiterpenoids (6–7) were isolated from Zingiberis Rhizoma. The structures of compounds (1–5) were determined by their 1D-NMR, 2D-NMR data and mass spectrometry. Their absolute configurations were determined by comparing their experimental and theoretically calculated ECD curve and quantum mechanical (QM) NMR approach. Compounds 2–7 were evaluated their cell viability, anti-apoptosis levels on human normal lung bronchial epithelial cells, which induced by lipopolysaccharide at 10 μM.