炎症性肠病
溃疡性结肠炎
泛素
免疫系统
全基因组关联研究
生物
结肠炎
发病机制
炎症
疾病
免疫学
医学
遗传学
基因
单核苷酸多态性
病理
基因型
作者
Jing Ruan,Dirk Schlüter,Michael Naumann,Ari Waisman,Xu Wang
标识
DOI:10.1016/j.molmed.2022.01.006
摘要
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder of the gastrointestinal tract. Although the pathophysiology of IBD is multifaceted, ubiquitination, a post-translational modification, has been shown to have essential roles in its pathogenesis and development. Ubiquitin-modifying enzymes (UMEs) work in synergy to orchestrate the optimal ubiquitination of target proteins, thereby maintaining intestinal homeostasis. Genome-wide association studies (GWAS) have identified multiple UME genes as IBD susceptibility loci, implying the importance of UMEs in IBD. Furthermore, accumulative evidence demonstrates that UMEs affect intestinal inflammation by regulating various aspects, such as intestinal barrier functions and immune responses. Considering the significant functions of UMEs in IBD, targeting UMEs could become a favorable therapeutic approach for IBD.
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