An efficient screening system to identify protein–protein or protein–DNA interaction partners of rice transcription factors

生物 能量稳态 瘦素 转录因子 食物摄入量 能量平衡 遗传学 食欲 内分泌学 内科学 细胞生物学 神经科学 基因 肥胖 医学 生态学
作者
Qingmei Su,Fang Zhang,Yunping Xiao,Ping Zhang,Hefei Xing,Fan Chen
出处
期刊:Journal of Genetics and Genomics [Elsevier BV]
卷期号:49 (10): 979-981 被引量:5
标识
DOI:10.1016/j.jgg.2022.02.007
摘要

Food intake is generally assumed to reflect a regulatory tension between homeostatic and hedonic drivers. Information from individuals with memory dysfunction suggests that episodic memory may also play a significant role. We reasoned that if memory influences food intake, then disrupting a genetic factor that is important in episodic memory formation should affect food intake and energy balance. We performed spatial learning tests on neuronal specific endophilin A1 (EENA1) KO mice using the four-arm baited version of the radial arms maze (RAM). Energy regulation has also been evaluated. As anticipated neuronal EENA1 KO mice had impaired spatial memory. However, loss of endophilin A1 did not result in greater food intake, or altered energy absorption efficiency, relative to wild-type (WT) mice, when fed either low or high fat diets. Moreover, loss of EENA1 did not significantly affect other features of energy balance—physical activity and energy expenditure. No statistically significant changes were observed in the expression of hypothalamic neuropeptides related to food intake regulation, or circulating levels of leptin. We conclude that food intake and energy balance are largely governed by homeostatic and hedonic processes, and when these processes are intact memory probably plays a relatively minor role in food intake regulation.
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