[Expert consensus on ensartinib in the treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer].

The mutation rate of anaplastic lymphoma kinase (ALK) in patients with non-small cell lung cancer is 3% to 7%. Due to its low mutation rate and better long-term survival compared with epidermal growth factor receptor-positive non-small cell lung cancer patients, therefore, it's called "diamond mutation". At present, there are three generations of ALK tyrosine kinase inhibitor (TKI) drugs in the world. The first-generation ALK-TKI drug approved in China is crizotinib, and the second-generation drugs are alectinib, ceritinib and ensartinib. Among them, ensartinib is an ALK-TKI domestically developed, and its efficacy is similar to that of alectinib. The main adverse event is transient rash, and compliance to ensartinib is better from the perspective of long-term survival of patients. The manifestation of rash caused by ensartinib is different from that of other ALK-TKI drugs. In order to facilitate clinical application and provide patients with more treatment options, under the guidance of the Committee of Cancer Rehabilitation and Palliative Care of China Anti-Cancer Association, this article collects and summarizes the common adverse reactions of ensartinib. Based on the clinical practice, a clear adverse classification and specific treatment plan are formulated, in order to provide a corresponding reference for clinicians to make more comprehensive clinical decisions.非小细胞肺癌患者间变性淋巴瘤激酶(ALK)突变率为3%~7%。与表皮生长因子受体阳性非小细胞肺癌患者比较，ALK突变非小细胞肺癌患者更易获得长期生存，因此，ALK突变被称为钻石突变。目前，在全球范围内，ALK-酪氨酸激酶抑制剂(TKI)药物已经有三代药物。中国已获批的ALK-TKI第一代药物为克唑替尼，第二代药物为阿来替尼、塞瑞替尼和恩沙替尼。恩沙替尼为中国自主原研的ALK-TKI，其疗效与阿来替尼相似，耐受性表现为一过性皮疹，从患者长期生存的角度而言，顺应性更好。恩沙替尼引起的皮疹表现与其他ALK-TKI药物不同，为了便于临床应用和为患者提供更多的治疗选择，在中国抗癌协会肿瘤康复与姑息治疗专业委员会的指导下，专家收集汇总了恩沙替尼常见的不良反应，并结合临床实践制定了明确的不良分级及具体处理方案，以期为临床医师提供相应的参考依据。.