Immunohistochemical evaluation of microvascular rarefaction in hypertensive humans and in spontaneously hypertensive rats

医学 自发性高血压大鼠 微血管 骨骼肌 内科学 原发性高血压 川地31 内分泌学 免疫组织化学 微循环 管腔(解剖学) 血压
作者
Silvia Paiardi,Luigi Fabrizio Rodella,Carolina De Ciuceis,Enzo Porteri,Gianluca E.M. Boari,Rita Rezzani,Nicola Rizzardi,Caterina Platto,Guido Alberto Massimo Tiberio,Stefano Maria Giulini,Damiano Rizzoni,Enrico Agabiti‐Rosei
出处
期刊:Clinical Hemorheology and Microcirculation [IOS Press]
卷期号:42 (4): 259-268 被引量:54
标识
DOI:10.3233/ch-2009-1195
摘要

No data are presently available about changes in capillary density in the skeletal muscle and in the brain of spontaneously hypertensive rats (SHR) in relation to the development of hypertension.We have investigated 4 week-old and 12 week-old SHR and age-matched normotensive Wistar-Kyoto controls (WKY). Microvessel density (MVD) in the cerebral cortex and in a skeletal muscle were evaluated in sections stained for CD31. We also evaluated MVD in the dermal tissue of normotensive subjects and essential hypertensive patients. Subcutaneous small resistance arteries were dissected and mounted in a micromyograph and the media to lumen ratio (M/L) was measured.A significant reduction in MVD in the skeletal muscle and in the brain of SHR was clearly observed at 12 weeks of age, after the development of hypertension, but not at 4 weeks of age (pre-hypertensive condition). In hypertensive patients a significant reduction in the dermal MVD and an inverse correlation between M/L and MVD was observed.Our results suggest that, in the brain and skeletal muscle of adult SHR after the development of hypertension, and in the derma of adult essential hypertensive patients microvascular rarefaction may occur.
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