Inflammatory bowel disease and risk of stroke: A meta-analysis of cohort studies

Stroke is a sudden onset of cerebral blood circulation disorder, it is the second leading cause of death as well as the major cause of disability worldwide [ [1] Donnan G.A. Fisher M. Macleod M. Davis S.M. Stroke. Lancet. 2008; 371: 1612-1623 Abstract Full Text Full Text PDF PubMed Scopus (2055) Google Scholar ]. On average, every 40 s, someone has a stroke and someone dies of one approximately every 4 min in the United States [ 1 Donnan G.A. Fisher M. Macleod M. Davis S.M. Stroke. Lancet. 2008; 371: 1612-1623 Abstract Full Text Full Text PDF PubMed Scopus (2055) Google Scholar , 2 Mozaffarian D. Benjamin E.J. Go A.S. et al. Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation. 2015; 131: e29-e322 Crossref PubMed Scopus (5715) Google Scholar ], which places a considerable burden on society. Therefore, the identification of primary prevention and new therapeutic approaches for stroke is crucial and should be a key public health priority.