清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

HDL cholesterol and stroke risk: The Multi-Ethnic Study of Atherosclerosis

冲程(发动机) 医学 危险系数 内科学 风险因素 胆固醇 民族 队列 置信区间 人口学 人类学 机械工程 工程类 社会学
作者
Samantha A. Reina,María M. Llabre,Matthew Allison,John T. Wilkins,Armando J. Mendez,Martinson Arnan,Neil Schneiderman,Ralph L. Sacco,Mercedes R. Carnethon,Joseph A. Delaney
出处
期刊:Atherosclerosis [Elsevier BV]
卷期号:243 (1): 314-319 被引量:69
标识
DOI:10.1016/j.atherosclerosis.2015.09.031
摘要

Background and purpose Accurate identification of risk factors for stroke is important for public health promotion and disease prevention. HDL cholesterol is a potential risk factor, yet its role in stroke risk is unclear, as is whether HDL cholesterol content or particle number might be a better indicator of stroke risk. Furthermore, the degree to which ethnicity moderates the risk is unknown. As such, the current study examines the associations between incident stroke and both HDL cholesterol concentration and particle number, and assesses the moderating role of race and ethnicity. Methods The sample is a racially diverse cohort of US adults between the ages of 45–84 years enrolled in the Multi-Ethnic Study of Atherosclerosis between 2000 and 2002 and followed until December 2011. The associations among cholesterol content and stroke risk, particle number and stroke risk, and the interaction with race were explored. Results The incidence of stroke was 2.6%. HDL cholesterol concentration (mmol/L) (Hazard Ratio (HR) = .56; 95% Confidence Interval (CI): .312–.988) and number of large HDL particles (μmol/L) (HR = .52, CI: .278–.956) were associated with lower stroke risk. When interactions with race were evaluated, the relationship between both HDL variables and stroke were significant in Blacks, but not other races. Conclusions Higher HDL cholesterol and a higher concentration of large particles are associated with lower risk of stroke in Blacks. Further research is needed to elucidate the mechanisms by which HDL subfractions may differentially affect stroke outcome in different races/ethnicities.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Lyanph完成签到 ,获得积分10
4秒前
16秒前
领导范儿应助科研通管家采纳,获得10
21秒前
CC发布了新的文献求助10
22秒前
Dreamhappy完成签到,获得积分10
32秒前
chichenglin完成签到 ,获得积分0
33秒前
56秒前
gszy1975发布了新的文献求助10
1分钟前
凤里完成签到 ,获得积分10
1分钟前
fogsea完成签到,获得积分0
1分钟前
yao完成签到 ,获得积分10
1分钟前
韩寒完成签到 ,获得积分10
1分钟前
王佳豪完成签到,获得积分10
1分钟前
路路完成签到 ,获得积分10
2分钟前
2分钟前
曹国庆完成签到 ,获得积分10
2分钟前
StonesKing完成签到,获得积分20
2分钟前
tmobiusx完成签到,获得积分10
2分钟前
xun完成签到,获得积分10
2分钟前
zzgpku完成签到,获得积分0
3分钟前
3分钟前
搜集达人应助ceeray23采纳,获得20
3分钟前
CC发布了新的文献求助10
3分钟前
愤怒的小鸟完成签到,获得积分10
3分钟前
清脆钧完成签到,获得积分20
3分钟前
风清扬完成签到,获得积分0
3分钟前
勤劳的颤完成签到 ,获得积分10
3分钟前
3分钟前
ceeray23发布了新的文献求助20
4分钟前
亭2007完成签到 ,获得积分10
4分钟前
4分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
4分钟前
斯文败类应助雪山飞龙采纳,获得10
4分钟前
qianci2009完成签到,获得积分10
4分钟前
共享精神应助sh1ro采纳,获得10
4分钟前
hahaha完成签到 ,获得积分10
4分钟前
5分钟前
1437594843完成签到 ,获得积分10
5分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990629
求助须知:如何正确求助?哪些是违规求助? 3532220
关于积分的说明 11256552
捐赠科研通 3271057
什么是DOI,文献DOI怎么找? 1805229
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234