Electrochemical Biosensors Based on Micro‐fabricated Devices for Point‐of‐Care Testing: A Review

Abstract Point‐of‐care testing (POCT) is becoming a hot research topic that allows rapid, on‐site, and non‐professional measurements outside the central laboratory. The micro‐fabricated devices prepared by various micro‐machining technologies have shown the advantages of low reagent consumption, high‐throughput samples, and wearability. This review presents the recent progress of electrochemical biosensors based on various micro‐fabricated devices for POCT and the corresponding electrochemical techniques. Signal amplification strategies based on enzyme and nanotechnology are also illustrated for the more sensitive POCT applications of these micro‐fabricated devices. Consequently, the trends and challenges of electrochemical biosensors based on micro‐fabricated devices in POCT diagnosis are discussed.