Decarboxylative coupling of glyoxylic acid and its acetal derivatives: A unique C1 formylation synthon

Glyoxylic acid and its acetal derivatives are low toxicity, easy handling and storage, high stability and easy availability. In addition, they are easy to perform decarboxylative cross-coupling reactions. Therefore, the decarboxylative cross-coupling of glyoxylic acid and its acetal derivatives are beginning to emerge. This review mainly focuses on the decarboxylative cross-coupling reactions using glyoxylic acid and its acetal derivatives as formylation agents.