PLGA公司
贝伐单抗
眼球后段
壳聚糖
渗透(战争)
药代动力学
巩膜
玻璃体内给药
药物输送
化学
血管内皮生长因子
药理学
眼科
纳米颗粒
材料科学
生物医学工程
医学
血管内皮生长因子受体
外科
化疗
癌症研究
纳米技术
视网膜
生物化学
有机化学
工程类
运筹学
作者
Jayamanti Pandit,Yasmin Sultana,Mohd. Aqil
标识
DOI:10.1016/j.carbpol.2021.118217
摘要
In several ocular diseases, vascular endothelial growth factor (VEGF) level has been found to be unregulated. Bevacizumab, an anti-VEGF drug, is the most commonly used off level drug for diabetic retinopathy (DR). The present study was to evaluate the chitosan-coated poly (lactide-co-glycolic acid) nanoparticles (CS-PLGA NPs) for sustained and effective delivery of bevacizumab to posterior ocular tissues. The penetration of NP through sclera was studied by confocal laser scanning microscopy (CLSM). For pharmacokinetic study, bevacizumab loaded NPs were administered into the rat eye through subconjunctival injection (SCJ) and pharmacokinetic parameters were compared to drug solution. CLSM and pharmacokinetic study showed better penetration of formulation and higher concentration of bevacizumab in posterior ocular tissues. In retinopathy model, CS-PLGA NPs by SCJ route showed more reduction of VEGF level in retina than the topical and intravitreal administration of formulation. Thus, CS-coated PLGA NPs can be potentially useful as carriers to target retina.
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