传出细胞增多
生物
细胞生物学
转录因子
黑腹果蝇
增强子
免疫学
遗传学
基因
巨噬细胞
体外
作者
Qian Zheng,Ning Gao,Qiling Sun,Xiaowen Li,Yanzhe Wang,Hui Xiao
出处
期刊:PLOS Genetics
[Public Library of Science]
日期:2021-12-03
卷期号:17 (12): e1009947-e1009947
被引量:6
标识
DOI:10.1371/journal.pgen.1009947
摘要
Efferocytosis is the process by which phagocytes recognize, engulf, and digest (or clear) apoptotic cells during development. Impaired efferocytosis is associated with developmental defects and autoimmune diseases. In Drosophila melanogaster , recognition of apoptotic cells requires phagocyte surface receptors, including the scavenger receptor CD36-related protein, Croquemort (Crq, encoded by crq ). In fact, Crq expression is upregulated in the presence of apoptotic cells, as well as in response to excessive apoptosis. Here, we identified a novel gene bfc ( booster for croquemort ), which plays a role in efferocytosis, specifically the regulation of the crq expression. We found that Bfc protein interacts with the zinc finger domain of the GATA transcription factor Serpent (Srp), to enhance its direct binding to the crq promoter; thus, they function together in regulating crq expression and efferocytosis. Overall, we show that Bfc serves as a Srp co-factor to upregulate the transcription of the crq encoded receptor, and consequently boosts macrophage efferocytosis in response to excessive apoptosis. Therefore, this study clarifies how phagocytes integrate apoptotic cell signals to mediate efferocytosis.
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