合成生物学
天然产物
生化工程
芳香植物
生物技术
化学
生物
有机化学
计算生物学
工程类
植物
作者
Liangxu Liu,Chaofeng Li,Jiawei Wang,Jun Ni,Ping Xu
出处
期刊:Chinese Journal of Biotechnology
日期:2021-06-25
卷期号:37 (6): 2010-2025
被引量:1
标识
DOI:10.13345/j.cjb.210074
摘要
Plant-derived aromatic natural products have important medicinal value and can be made into pharmaceutical and healthcare products with antibacterial, anti-inflammatory, analgesic, anti-oxidative, insecticidal and anthelmintic, expectorant and cough suppressant, tranquilizer and antitumor effects. However, the low content of aromatic natural products in plants and the difficulty and high costs in extraction and purification hampered its large-scale production and application. Recent advances in synthetic biology and metabolic engineering have enabled the tailor-made production of aromatic natural products using engineered microbial cell factories. This review summarizes the categories, the synthetic pathways, the key enzymes and the synthetic biology strategies for production of aromatic natural products, and discusses the challenges and opportunities in this area.
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