细胞激素风暴
冠状病毒
中东呼吸综合征冠状病毒
激酶
急性呼吸窘迫综合征
冠状病毒科
病毒复制
病毒学
病毒生命周期
免疫学
病毒进入
病毒
医学
细胞生物学
生物
2019年冠状病毒病(COVID-19)
疾病
肺
传染病(医学专业)
病理
内科学
作者
Thanigaimalai Pillaiyar,Stefan Laufer
标识
DOI:10.1021/acs.jmedchem.1c00335
摘要
The global coronavirus disease-19 (COVID-19) has affected more than 140 million and killed more than 3 million people worldwide as of April 20, 2021. The novel human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been identified as an etiological agent for COVID-19. Several kinases have been proposed as possible mediators of multiple viral infections, including life-threatening coronaviruses like SARS-CoV-1, Middle East syndrome coronavirus (MERS-CoV), and SARS-CoV-2. Viral infections hijack abundant cell signaling pathways, resulting in drastic phosphorylation rewiring in the host and viral proteins. Some kinases play a significant role throughout the viral infection cycle (entry, replication, assembly, and egress), and several of them are involved in the virus-induced hyperinflammatory response that leads to cytokine storm, acute respiratory distress syndrome (ARDS), organ injury, and death. Here, we highlight kinases that are associated with coronavirus infections and their inhibitors with antiviral and potentially anti-inflammatory, cytokine-suppressive, or antifibrotic activity.
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