过氧化氢
谷胱甘肽
纳米点
铜
肿瘤微环境
活性氧
内吞作用
二价
材料科学
生物物理学
羟基自由基
催化作用
细胞凋亡
化学
核化学
光化学
细胞
激进的
生物化学
癌症研究
纳米技术
肿瘤细胞
生物
有机化学
酶
作者
Yanan Hao,Yiru Gao,You Li,Fei Teng,Yang Shu,Jianhua Wan
标识
DOI:10.1002/admi.202101173
摘要
Abstract An ultrasmall chemodynamic therapeutic (CDT) agent with favorable specificity to tumor microenvironment, i.e., high level of glutathione (GSH) and hydrogen peroxide (H 2 O 2 ), is reported. The coordination polymer nanodot between divalent copper (Cu 2+ ) and gallic acid (GA) is shortly named as Cu–GA. The ultrasmall size of Cu–GA (2.16 ± 0.3 nm) results in a large specific surface area, which is beneficial for improving its catalytic performance. After endocytosis into tumor cell interior, Cu–GA promotes GSH‐activated and H 2 O 2 ‐reinforced CDT in situ, wherein divalent Cu(II) is reduced to monovalent Cu(I) by GSH and induced GSH depletion. Subsequently, the generated Cu(I) catalyzes local H 2 O 2 to generate toxic hydroxyl radical (•OH) via Fenton‐like reaction, and •OH leads to tumor cell apoptosis. The higher levels of GSH and H 2 O 2 in the tumor cell interior significantly improve the efficiency of CDT, and meanwhile protect the normal cells. In addition, the ultrasmall size of Cu–GA facilitates its fast clearance and eliminates long‐term body retention, with minimized systemic toxicity during the treatment in vivo. Therefore, as a novel copper‐based nanoformulation specifically responsive to the tumor microenvironment, Cu–GA provides promising potentials in CDT.
科研通智能强力驱动
Strongly Powered by AbleSci AI