青枯菌
部分
化学
稻黄单胞菌
EC50型
野油菜黄单胞菌
抗菌活性
酰胺
体内
立体化学
南方根结线虫
体外
微生物学
细菌
有机化学
生物化学
线虫
病菌
生物
生物技术
生态学
基因
遗传学
作者
Jixiang Chen,Chongfen Yi,Shaobo Wang,Sikai Wu,Shaoyuan Li,Deyu Hu,Baoan Song
标识
DOI:10.1016/j.bmcl.2019.03.017
摘要
A series of novel amide derivatives containing 1,3,4-thiadiazole moiety were synthesized and their bioactivities were evaluated. The compound 34 exhibited good nematocidal activities against Meloidogyne incognita in vitro and in vivo, the LC50 value and control effect were 6.5 mg/L and 83.3%, respectively. Meanwhile, it exhibited exciting antibacterial activities against Xanthomonas oryzae pv. oryzae, Xanthomonas campestris pv. citri, and Ralstonia solanacearum, the EC50 values were 0.4, 6.7 and 5.1 mg/L, respectively, which were better than positive controls. The curative and protection activities under the greenhouse conditions of compound 34 against rice bacterial blight were 47.9 and 55.8%, respectively. The structure-activity relationship were analyzed in detail.
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