Soluble TREM2 changes during the clinical course of Alzheimer’s disease: A meta-analysis

特雷姆2 医学 内科学 科克伦图书馆 荟萃分析 神经炎症 生物标志物 肿瘤科 子群分析 严格标准化平均差 临床痴呆评级 痴呆 阿尔茨海默病 队列 疾病 受体 生物 髓系细胞 生物化学
作者
Dan Liú,Bing Cao,Yujia Zhao,Haixia Huang,Roger S. McIntyre,Joshua D. Rosenblat,Hui Zhou
出处
期刊:Neuroscience Letters [Elsevier BV]
卷期号:686: 10-16 被引量:68
标识
DOI:10.1016/j.neulet.2018.08.038
摘要

Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a potential and novel biomarker of neuroinflammation implicated in the onset and progression of Alzheimer’s disease (AD). However, previous studies evaluating levels of sTREM2 in different clinical stages of AD have yielded inconsistent results. To clarify the dynamic change of sTREM2 in AD progression, we conducted a meta-analysis of case-control and cohort studies to determine the role of cerebral spinal fluid (CSF) and plasma sTREM2 levels in preclinical AD (pre-AD), mild cognitive impairment (MCI) and AD dementia. We searched PubMed, MEDLINE, EMBASE, the Cochrane Library for English articles and Sinomed, CNKI for Chinese. The associations between sTREM2 levels and AD continuum groups (pre-AD, MCI and AD) were analyzed. We further performed detailed subgroup analysis and meta-regression to detect the sources of heterogeneity. 17 reports comprising 82 patients with pre-AD, 159 with MCI, 598 with AD, as well as 754 controls were included in this analysis. Regarding the sTREM2 levels in CSF, the overall pooled standard mean difference (SMD) revealed significantly elevated sTREM2 levels in the whole AD continuum groups (SMD = 0.48; 95% CI: 0.23, 0.73; P < 0.001) compared with controls. The levels of sTREM2 significantly increased in pre-AD (SMD = 0.47; 95% CI: 0.21, 0.73; P < 0.001), the highest increase occurred in MCI group (SMD = 0.77; 95% CI: -0.05, 1.59; P = 0.066), and the effect size of AD group (SMD = 0.39; 95% CI: 0.13, 0.65; P = 0.004) was also higher compared with control. However, for sTREM2 levels measured in plasma, no significant differences were found (SMD = 0.11; 95% CI: -0.06, 0.27; P = 0.217). Therefore, our study showed that sTREM2 levels increased in the earlier course of AD, and slightly attenuated in dementia stage. The current results indicated that sTREM2 levels fluctuate as a function of clinical stage in AD and it might be a novel inflammatory biomarker involved in different stages of AD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI5应助高贵的如曼采纳,获得10
1秒前
sandra发布了新的文献求助10
1秒前
FF完成签到 ,获得积分10
2秒前
Wangyicong发布了新的文献求助10
3秒前
3秒前
3秒前
艺善艺善亮晶晶完成签到,获得积分10
4秒前
shinysparrow应助Mollymama采纳,获得100
4秒前
栗子鱼完成签到,获得积分10
6秒前
yuko完成签到 ,获得积分10
6秒前
ChatGPT发布了新的文献求助10
7秒前
科研通AI5应助xn201120采纳,获得150
8秒前
8秒前
刀锋发布了新的文献求助10
8秒前
9秒前
传奇3应助baibai采纳,获得10
10秒前
菠萝冰棒完成签到 ,获得积分10
10秒前
Laurel发布了新的文献求助10
12秒前
汤博森发布了新的文献求助10
12秒前
Elody完成签到,获得积分20
12秒前
13秒前
桐桐应助小周碎碎念采纳,获得10
14秒前
刀锋完成签到,获得积分10
16秒前
大模型应助You采纳,获得10
19秒前
顺心夏山发布了新的文献求助10
19秒前
Jasper应助morena采纳,获得10
20秒前
20秒前
22秒前
23秒前
23秒前
满意的西牛完成签到,获得积分10
24秒前
26秒前
27秒前
阳光凡儿发布了新的文献求助10
27秒前
baba完成签到 ,获得积分20
29秒前
30秒前
公孙世往发布了新的文献求助10
30秒前
31秒前
白开水完成签到,获得积分10
32秒前
Giny完成签到,获得积分10
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976267
求助须知:如何正确求助?哪些是违规求助? 3520472
关于积分的说明 11203425
捐赠科研通 3257089
什么是DOI,文献DOI怎么找? 1798589
邀请新用户注册赠送积分活动 877785
科研通“疑难数据库(出版商)”最低求助积分说明 806523