Low-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications

神经调节 人脑 经颅多普勒 超声 超声波 神经科学 医学 心理学 放射科 中枢神经系统
作者
Anton Fomenko,Clemens Neudorfer,Robert F. Dallapiazza,Suneil K. Kalia,Andrés M. Lozano
出处
期刊:Brain Stimulation [Elsevier]
卷期号:11 (6): 1209-1217 被引量:228
标识
DOI:10.1016/j.brs.2018.08.013
摘要

Background There is an emerging need for noninvasive neuromodulation techniques to improve patient outcomes while minimizing adverse events and morbidity. Low-intensity focused ultrasound (LIFUS) is gaining traction as a non-surgical experimental approach of modulating brain activity. Several LIFUS sonication parameters have been found to potentiate neural firing, suppress cortical and epileptic discharges, and alter behavior when delivered to cortical and subcortical mammalian brain regions. Objective This review introduces the elements of an effective sonication protocol and summarizes key preclinical studies on LIFUS as a neuromodulation modality. The state of the art in human ultrasound neuromodulation is then comprehensively summarized, and current hypotheses regarding the underlying mechanism of action on neural activity are presented. Methods Peer-reviewed literature on human ultrasound neuromodulation was obtained by searching several electronic databases. The abstracts of all reports were read and publications which examined low-intensity transcranial ultrasound applied to human subjects were selected for review. Results LIFUS can noninvasively influence human brain activity by suppressing cortical evoked potentials, influencing cortical oscillatory dynamics, and altering outcomes of sensory/motor tasks compared to sham sonication. Proposed mechanisms include cavitation, direct effects on neural ion channels, and plasma membrane deformation. Conclusions Though optimal sonication paradigms and transcranial delivery methods are still being established, future applications may include non-invasive human brain mapping experiments, and nonsurgical treatments for functional neurological disorders.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
酷酷的糖豆完成签到,获得积分20
2秒前
NexusExplorer应助xiu采纳,获得10
2秒前
nenoaowu发布了新的文献求助30
4秒前
小鲁发布了新的文献求助10
5秒前
7秒前
suodeheng发布了新的文献求助50
7秒前
丽江阿镇完成签到,获得积分10
8秒前
欣喜数据线完成签到,获得积分10
8秒前
LYT应助苹果初雪采纳,获得10
11秒前
12秒前
xiu完成签到,获得积分10
12秒前
123发布了新的文献求助10
13秒前
汉堡包应助nenoaowu采纳,获得10
13秒前
13秒前
13秒前
14秒前
16秒前
安静凡旋发布了新的文献求助10
18秒前
18秒前
18秒前
隐形曼青应助草莓熊采纳,获得10
19秒前
上官若男应助大兵采纳,获得10
19秒前
chuhong发布了新的文献求助10
19秒前
123完成签到,获得积分10
21秒前
22秒前
23秒前
Ava应助三斤橙子采纳,获得10
24秒前
Hemingwayway发布了新的文献求助10
24秒前
科研通AI5应助汉堡麻麻采纳,获得10
25秒前
搜集达人应助段落落采纳,获得10
28秒前
vivi发布了新的文献求助10
29秒前
JackDean完成签到 ,获得积分10
30秒前
共享精神应助Hemingwayway采纳,获得10
31秒前
31秒前
风123完成签到 ,获得积分10
31秒前
风123关注了科研通微信公众号
33秒前
33秒前
草莓熊完成签到,获得积分10
33秒前
cookie完成签到 ,获得积分10
35秒前
zzy发布了新的文献求助10
35秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 610
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Virulence Mechanisms of Plant-Pathogenic Bacteria 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3561543
求助须知:如何正确求助?哪些是违规求助? 3135129
关于积分的说明 9411323
捐赠科研通 2835648
什么是DOI,文献DOI怎么找? 1558529
邀请新用户注册赠送积分活动 728347
科研通“疑难数据库(出版商)”最低求助积分说明 716791