Comparison of Clinical Outcomes of Prostatic Artery Embolization with 50-μm Plus 100-μm Polyvinyl Alcohol (PVA) Particles versus 100-μm PVA Particles Alone: A Prospective Randomized Trial

医学 国际前列腺症状评分 下尿路症状 前列腺 不利影响 泌尿科 生活质量(医疗保健) 随机对照试验 增生 外科 内科学 癌症 护理部
作者
Mao Qiang Wang,Jin Long Zhang,Hai Nan Xin,Kai Yuan,Jieyu Yan,Yan Wang,Guo Dong Zhang,Jinxin Fu
出处
期刊:Journal of Vascular and Interventional Radiology [Elsevier]
卷期号:29 (12): 1694-1702 被引量:55
标识
DOI:10.1016/j.jvir.2018.06.019
摘要

Purpose To evaluate the safety and efficacy of prostatic artery embolization (PAE) using the combination of 50-μm and 100-μm polyvinyl alcohol (PVA) particles versus 100-μm PVA particles alone in the treatment of patients with symptomatic benign prostatic hyperplasia (BPH). Materials and Methods Over a 5-year period, 120 patients treated with PAE for lower urinary tract symptoms (LUTS) secondary to BPH were randomized to undergo embolization with 50-μm plus 100-μm PVA particles (group A) or 100-μm PVA particles alone (group B). Mean follow-up time was 34 months (range, 12–57 mo). There were no differences between groups regarding baseline data. Primary outcome measurements included change in International Prostate Symptom Score (IPSS) and incidence of adverse events. Secondary outcome measurements included procedure-associated pain, prostate ischemia measured on magnetic resonance (MR) imaging 1 week after PAE, and changes over time in quality of life (QOL) questionnaire, peak urinary flow rate (Qmax), postvoid residual (PVR) volume, prostate volume (PV), prostate-specific antigen (PSA) level, and International Index of Erectile Function (IIEF) were evaluated. Recurrence of LUTS following PAE was defined as relief of LUTS temporally but increased IPSS ≥ 8 or QOL score ≥ 3 or decrease in Qmax to < 7 mL/s. Results Mean follow-up periods were 35 months ± 22 in group A and 33 months ± 25 in group B (P = .629). No differences between groups regarding procedural details, pain scores, or adverse events were noted (P > .05). At 24 month of follow-up, patients in group A had a greater decrease in mean IPSS (18.7 ± 12.5 vs 14.8 ± 13.5), QOL score (3.7 ± 1.5 vs 2.4 ± 1.8), Qmax (10.5 mL ± 9.5 vs 6.8 mL ± 5.0), PVR (92.0 mL ± 75.0 vs 60.0 mL ± 55.0), and PV (37.0 mL ± 19.5 vs 25.5 mL ± 15.0) compared with patients in group B (P < .05 for all). Mean ratios of prostate ischemic volume at 1 week after PAE were 70% ± 20 in group A and 41% ± 25 in group B (P = .021); mean PSA levels at 24 hour after PAE were 92.5 ng/mL ± 55.0 in group A and 77.5 ng/mL ± 45.0 in group B (P = .031); LUTS recurrence rates were 3.6% in group A and 14.6% in group B (P = .024). The mean IIEF-5 was not significantly different from baseline in either group. Conclusions PAE with 50-μm plus 100-μm PVA particles resulted in greater improvement in clinical and imaging outcomes and no significant differences in adverse events compared with 100-μm PVA particles alone.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
HMONEY完成签到,获得积分10
1秒前
汉堡包应助光翟君采纳,获得10
1秒前
1秒前
霁星河完成签到,获得积分20
2秒前
Wang完成签到,获得积分10
2秒前
3秒前
3秒前
Dongfu_FA完成签到,获得积分10
4秒前
5秒前
小凉完成签到,获得积分10
5秒前
6秒前
zdw发布了新的文献求助10
6秒前
Candle完成签到,获得积分20
6秒前
6秒前
stuffmatter应助Dongfu_FA采纳,获得10
6秒前
丘比特应助Dongfu_FA采纳,获得10
6秒前
qurrr发布了新的文献求助10
7秒前
喵喵完成签到,获得积分10
8秒前
ZiyueNiu发布了新的文献求助10
8秒前
8秒前
小蘑菇应助俯冲食堂采纳,获得10
9秒前
9秒前
小约翰完成签到,获得积分20
10秒前
10秒前
碳酸芙兰发布了新的文献求助10
10秒前
10秒前
Adam发布了新的文献求助10
11秒前
科研通AI2S应助dealin采纳,获得10
11秒前
12秒前
12秒前
善学以致用应助榴下晨光采纳,获得10
12秒前
13秒前
13秒前
旖旎发布了新的文献求助10
14秒前
可爱的函函应助机智雁梅采纳,获得10
14秒前
14秒前
15秒前
婷婷完成签到,获得积分10
15秒前
16秒前
豆豆发布了新的文献求助10
16秒前
高分求助中
Sustainability in ’Tides Chemistry 2000
The ACS Guide to Scholarly Communication 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3075498
求助须知:如何正确求助?哪些是违规求助? 2728589
关于积分的说明 7505148
捐赠科研通 2376734
什么是DOI,文献DOI怎么找? 1260264
科研通“疑难数据库(出版商)”最低求助积分说明 610928
版权声明 597149