钙
细胞质
钙化
程序性细胞死亡
体内
细胞
癌细胞
癌症研究
化学
生物物理学
癌症
医学
细胞生物学
生物化学
病理
细胞凋亡
内科学
生物
有机化学
生物技术
作者
Meng Zhang,Ruixue Song,Yanyan Liu,Zhigao Yi,Xianfu Meng,Jiawen Zhang,Zhongmin Tang,Zhenwei Yao,Yang Liu,Xiaogang Liu,Wenbo Bu
出处
期刊:Chem
[Elsevier]
日期:2019-07-03
卷期号:5 (8): 2171-2182
被引量:361
标识
DOI:10.1016/j.chempr.2019.06.003
摘要
Calcium overload, characterized by an abnormal cytoplasm accumulation of free calcium ions (Ca2+), is a widely recognized cause of damage in numerous cell types and even of cell death. This undesirable destructive process can become a new tool applicable to cancer treatment. Herein, on the basis of the unique biological effect of Ca2+, we demonstrate a highly efficient strategy for tumor therapy by utilizing pH-sensitive sodium-hyaluronate-modified calcium peroxide nanoparticles (SH-CaO2 NPs). These NPs create an artificial calcium overloading stress in tumor cells, which is responsible for cell death. Notably, the killing effect is not limited to tumor types or hypoxic cells, and normal cells are more tolerant of the adverse influence of NPs than tumor cells. The Ca2+ enrichment also increases the likelihood of tumor calcification, which could contribute to in vivo tumor inhibition and facilitate medical imaging to monitor the treatment efficacy.
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