生物材料
组织工程
再生(生物学)
生物相容性材料
再生医学
主机响应
免疫系统
功能(生物学)
细胞生物学
生物
生物医学工程
医学
干细胞
免疫学
作者
Ajaykumar Vishwakarma,Nupura S. Bhise,Marta B. Evangelista,Jeroen Rouwkema,Mehmet R. Dokmeci,Amir M. Ghaemmaghami,Nihal Engin Vrana,Ali Khademhosseini
标识
DOI:10.1016/j.tibtech.2016.03.009
摘要
Current state-of-the-art biomedical implants and tissue engineering methods promise technologies to improve or even restore the function of diseased organs. However, one of the biggest challenges to clinical success is the lack of functional integration. A series of cellular and molecular events following biomaterial implantation poses an important bottleneck for developing breakthrough solutions. With inflammation increasingly recognized as a crucial component influencing regeneration, immunomodulation or immuno-engineering has emerged as a potential solution to overcome this key challenge in regenerative medicine. We postulate possibilities to utilize biomaterial physicochemical modifications to modulate the host inflammatory response and develop strategies for effective biomaterial integration. Biomaterial-based immunomodulation strategies can significantly ameliorate the outcomes of medical implants and tissue engineering therapies.
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