Distribution of GABAA, GABAB, and glycine receptors in the central auditory system of the big brown bat,Eptesicus fuscus

Journal of Comparative NeurologyVolume 369, Issue 1 p. 83-92 Distribution of GABAA, GABAB, and glycine receptors in the central auditory system of the big brown bat, Eptesicus fuscus Boma M. Fubara, Boma M. Fubara Departments of Neurobiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710Search for more papers by this authorJohn H. Casseday, John H. Casseday Departments of Neurobiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710Search for more papers by this authorEllen Covey, Corresponding Author Ellen Covey Departments of Neurobiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710Department of Psychology, Box 351525, The University of Washington, Seattle, WA 98195Search for more papers by this authorRochelle D. Schwartz-Bloom, Rochelle D. Schwartz-Bloom Departments of Neurobiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710Search for more papers by this author Boma M. Fubara, Boma M. Fubara Departments of Neurobiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710Search for more papers by this authorJohn H. Casseday, John H. Casseday Departments of Neurobiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710Search for more papers by this authorEllen Covey, Corresponding Author Ellen Covey Departments of Neurobiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710Department of Psychology, Box 351525, The University of Washington, Seattle, WA 98195Search for more papers by this authorRochelle D. Schwartz-Bloom, Rochelle D. Schwartz-Bloom Departments of Neurobiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710Search for more papers by this author First published: 20 May 1996 https://doi.org/10.1002/(SICI)1096-9861(19960520)369:1<83::AID-CNE6>3.0.CO;2-GCitations: 72AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Quantitative autoradiographic techniques were used to compare the distribution of GABAA, GABAB, and glycine receptors in the subcortical auditory pathway of the big brown bat, Eptesicus fuscus. For GABAA receptors, the ligand used was 35S-t-butylbicyclophosphorothionate (TBPS); for GABAB receptors, 3H-GABA was used as a ligand in the presence of isoguvacine to block binding to GABAA sites; for glycine, the ligand used was 3H-strychnine. In the subcortical auditory nuclei there appears to be at least a partial complementarity in the distribution of GABAA receptors labeled with 35S-TBPS and glycine receptors labeled with 3H-strychnine. GABAA receptors were concentrated mainly in the inferior colliculus (IC) and medial geniculate nucleus, whereas glycine receptors were concentrated mainly in nuclei below the level of the IC. Within the IC, there was a graded spatial distribution of 35S-TBPS binding; the most dense labeling was in the dorsomedial region, but very sparse labeling was observed in the ventrolateral region. There was also a graded spatial distribution of 3H-strychnine binding. 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