Bcl-2 protein and acute renal ischemia-reperfusion injury

Ischemia-reperfusion after neonatal asphyxia is a key factor in renal injury,which often can lead to apoptosis of tubular epithelial cells.Apoptosis is an important form of injury for renal tubular epithelial cells after asphyxia.Large number of cancer genes involve in regulation of renal ischemia-reperfusion injury in the process of apoptosis.Bcl-2 protein which are expression products of Bcl-2 oncogene act on the mitochondrial pathway in apoptosis.Furthermore they can inhibit the caspase cascade of apoptosis via the cells cross-talk,which contribute to attenuate renal ischemia-reperfusion injury and improve renal function. Key words: Bcl-2 protein; Apoptosis; Kidney; Ischemia-reperfusion injury