Myopenic obesity determined by visceral fat area strongly predicts long-term mortality in cirrhosis

医学 内科学 胃肠病学 肝硬化 肥胖 体质指数 多元分析 肥胖悖论 比例危险模型 肌萎缩 超重
作者
Hongjuan Feng,Xiaoyu Wang,Tianming Zhao,Leilei Mao,Yangyang Hui,Xiaofei Fan,Lin Lin,Wei Zhao,Kui Jiang,Bangmao Wang,Qing Yu,Jie Zhang,Chao Sun
出处
期刊:Clinical Nutrition [Elsevier BV]
卷期号:40 (4): 1983-1989 被引量:18
标识
DOI:10.1016/j.clnu.2020.09.016
摘要

Summary

Background

The impact of changes in body composition has proved to correlate with outcomes in cirrhosis, however, numerous issues remain elusive. The present study aimed to investigate the prognostic value of myopenic obesity (MO) on long-term mortality in cirrhosis.

Methods

We retrospectively analyzed 200 patients with cirrhosis. Body composition parameters including skeletal muscle index (SMI) and visceral fat area (VFA) were estimated by computed tomography images at the third lumbar vertebra level. We defined MO as a low SMI (male: SMI < 46.96 cm2/m2 and female: SMI < 32.46 cm2/m2) with BMI ≥ 25 kg/m2 or VFA ≥ 100 cm2 according to our previous publication. Patients were categorized into one of four body composition groups in terms of the presence or absence of myopenia and obesity.

Results

On the basis of VFA or BMI, the four group comparison demonstrated the prognosis was poor in MO, followed by myopenic/nonobesity (MN), nonmyopenic/obesity and nonmyopenic/nonobesity, in that order (log-rank test). Multivariate Cox analysis identified that MO (HR 2.498; 95% CI, 1.214–5.140; P = 0.013), MN (HR 2.763; 95% CI, 1.244–6.134; P = 0.013), age (HR 3.035; 95% CI, 1.904–4.839; P < 0.001), neutrophil-to-lymphocyte ratio (HR 1.142; 95% CI, 1.082–1.207; P < 0.001) and MELD (HR 1.140; 95% CI, 1.066–1.219; P = 0.001) were independently associated with 2-year mortality according to VFA classification.

Conclusions

MO was an independent predictor of higher long-term mortality in cirrhosis. Prevention strategies by reducing visceral fat obesity rather than BMI should be the optimal target for MO management.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
GGBOND发布了新的文献求助10
刚刚
2秒前
hhhblabla应助yyyyyyy111采纳,获得10
4秒前
哈哈发布了新的文献求助10
5秒前
10秒前
12秒前
背后初南完成签到,获得积分10
13秒前
神勇馒头完成签到,获得积分10
13秒前
GGBOND发布了新的文献求助10
14秒前
14秒前
15秒前
以戈完成签到,获得积分10
17秒前
19秒前
泡泡脑瓜发布了新的文献求助10
20秒前
358489228完成签到,获得积分10
20秒前
21秒前
xww发布了新的文献求助10
23秒前
24秒前
神勇馒头发布了新的文献求助10
27秒前
27秒前
chen完成签到,获得积分10
29秒前
cindywu发布了新的文献求助10
29秒前
贰叁发布了新的文献求助10
30秒前
31秒前
量子星尘发布了新的文献求助10
32秒前
33秒前
Lu发布了新的文献求助10
35秒前
36秒前
泡泡脑瓜关注了科研通微信公众号
37秒前
丫丫丫完成签到,获得积分20
38秒前
无花果应助GGBOND采纳,获得10
38秒前
跳跃盼波完成签到,获得积分10
40秒前
喜悦松完成签到,获得积分10
41秒前
666完成签到,获得积分10
41秒前
Jessica完成签到,获得积分10
44秒前
44秒前
汉堡包应助666采纳,获得10
45秒前
Hello应助贰叁采纳,获得10
45秒前
上官若男应助hugdoggy采纳,获得10
47秒前
emmm完成签到,获得积分10
47秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105