肠道菌群
中医药
生物
鉴定(生物学)
计算生物学
医学
免疫学
生态学
病理
替代医学
作者
Tzu-Lung Lin,David M. Ojcius,Wei-Fan Lai,Ting‐Shu Wu,Jang‐Jih Lu,Young-Mao Chen,Chi-Meng Tzeng,Hongtao Liu,Hong Wei,Hsin‐Chih Lai
出处
期刊:Protein & Cell
[Springer Nature]
日期:2020-09-15
卷期号:12 (5): 394-410
被引量:87
标识
DOI:10.1007/s13238-020-00784-w
摘要
Abstract Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.
科研通智能强力驱动
Strongly Powered by AbleSci AI