苦瓜
氧化应激
秀丽隐杆线虫
活性氧
抗氧化剂
皂甙
丙二醛
化学
食品科学
多糖
药理学
生物化学
传统医学
生物
医学
基因
替代医学
病理
作者
Chunxiu Lin,Yizi Lin,Jie Xiao,Yaqi Lan,Yong Cao,Yunjiao Chen
摘要
Abstract BACKGROUND As an edible and medicinal herb in Chinese folk medicine, Cyclocarya paliurus (Batal.) Iljinskaja leaves are traditionally widely used in the treatment of metabolic disorders. The vegetable Momordica charantia L. has been consumed worldwide for thousands of years as a traditional drug due to its activities against obesity and diabetes. In view of the therapeutic value of Momordica saponins (MSs) and C. paliurus polysaccharides (CPPs), an independently developed MSs‑ and CPPs‐containing beverage (MC) was evaluated for its efficacy in controlling oxidative stress and obesity in Caenorhabditis elegans . RESULTS First, we found that MC could promote the nuclear localization of DAF‐16 and the translation of SOD‐3. Further exploring its antioxidant properties, the oxidative stress by‐products reactive oxygen species, malondialdehyde, and nonesterified fatty acids were significantly inhibited in C. elegans . Moreover, damage due to diseases related to oxidative stress (age pigments and neurodegenerative diseases) was alleviated. Furthermore, fat accumulation was significantly reduced in normal and high‐fat models. Finally, the lipid‐lowering effects of MC might involve reductions in the size and number of lipid droplets without impairing basic physiological functions in C. elegans . CONCLUSION These results provide promising data indicating MC as an innovative health beverage for the pharmacological management of oxidative stress and obesity. © 2020 Society of Chemical Industry.
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