对映选择合成
化学
催化作用
立体化学
组合化学
生物化学
作者
Georgi R. Genov,James L. Douthwaite,Antti S. K. Lahdenperä,David C. Gibson,Robert J. Phipps
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2020-03-12
卷期号:367 (6483): 1246-1251
被引量:276
标识
DOI:10.1126/science.aba1120
摘要
Chiral cations have been used extensively as organocatalysts, but their application to rendering transition metal-catalyzed processes enantioselective remains rare. This is despite the success of the analogous charge-inverted strategy in which cationic metal complexes are paired with chiral anions. We report here a strategy to render a common bipyridine ligand anionic and pair its iridium complexes with a chiral cation derived from quinine. We have applied these ion-paired complexes to long-range asymmetric induction in the desymmetrization of the geminal diaryl motif, located on a carbon or phosphorus center, by enantioselective C-H borylation. In principle, numerous common classes of ligand could likewise be amenable to this approach.
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