前列腺癌
色丛
遗传异质性
生物
癌症
外显子组测序
癌变
癌症的体细胞进化
基因组不稳定性
转移
拷贝数变化
前列腺
癌症研究
突变
遗传学
基因
基因组
DNA损伤
PCA3系列
表型
DNA
作者
Bo Wu,Xin Lü,Haibo Shen,Xiaobin Yuan,Xin Wang,Nan Yin,Libin Sun,Pengliang Shen,Caoyang Hu,Huanrong Jiang,Dongwen Wang
摘要
Prostate cancer is a heterogeneous disease and optimum gene targeting treatment is often impermissible. We aim to determine the intratumoral genomic heterogeneity of prostate cancer and explore candidate genes for targeted therapy. Exome sequencing was performed on 37 samples from 16 patients with prostate cancer. Somatic variant analysis, copy number variant (CNV) analysis, clonal evolution analysis and variant spectrum analysis were used to study the intratumoral genomic heterogeneity and genetic characteristics of metastatic prostate cancer. Our study confirmed the high intratumoral genetic heterogeneity of prostate cancer in many aspects, including number of shared variants, tumor mutation burden (TMB), variant genes, CNV burden, weighted genome instability index (wGII), CNV profiles, clonal evolutionary process, variant spectrum and mutational signatures. Moreover, we identified several common genetic characteristics of prostate cancer. Alterations of DNA damage repair genes, RTK/RAS pathway associated gene RASGRF1 and autophagy gene EPG5 may be involved in tumorigenesis in prostate cancer. CNV burden and DNA damage repair (DDR) genes may be associated with metastasis of prostate cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI