表皮生长因子受体
ERBB3型
信号转导
癌症研究
ErbB公司
表皮生长因子
受体酪氨酸激酶
酪氨酸激酶
细胞周期蛋白依赖激酶8
调节器
生长因子受体
表皮生长因子受体抑制剂
化学
生物
生长因子受体抑制剂
细胞生物学
受体
生物化学
基因
Notch信号通路
作者
Dima A. Sabbah,Rima Hajjo,Kamal Sweidan
标识
DOI:10.2174/1568026620666200303123102
摘要
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.
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