有条件地点偏好
冰毒-
甲基苯丙胺
蛋白磷酸酶2
消光(光学矿物学)
上瘾
药理学
化学
磷酸酶
心理学
神经科学
生物
磷酸化
生物化学
有机化学
矿物学
聚合物
丙烯酸酯
单体
作者
Hongyan Qian,Jing Wang,Qing Shang,Jing Xiao,Gang Chen,Baoyao Gao,Min Liang,Tao Li,Xinshe Liu
标识
DOI:10.1016/j.neulet.2020.134817
摘要
Protein phosphatase 2A (PP2A) is an evolutionarily conserved serine/threonine phosphatase abundant in mammalian brains. Although recent research has revealed that PP2A plays important roles in cocaine and morphine addictions, the mechanism of action of PP2A in methamphetamine (METH) addiction is unclear. LB100 is a PP2A inhibitor able to penetrate the blood-brain barrier (BBB); the role of LB100 in METH-induced conditioned place preference (CPP) has not yet been reported. Here, we explored the roles of LB100 in distinct phases of METH-induced CPP. Our findings indicate that LB100 inhibits the acquisition and reinstatement of METH-induced CPP and promotes the extinction of METH-induced CPP. Moreover, LB100 alone did not affect the natural preference of mice. Intriguingly, repeated administration of LB100 in the extinction phase did not inhibit the reinstatement of METH-induced CPP, but LB100 injection prior to METH administration could significantly block it. Taken together, we found that LB100 has significant effects on different phases of METH-induced CPP, and is therefore, a potentially promising therapeutic for METH addiction.
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