Research progress in tranexamic acid for reducing perioperative hidden blood loss in intertrochanteric fracture of femur

Intertrochanteric fracture of femur (IFF) is a common fracture type in traumatic orthopedics, which seriously affects patients' quality of life and health. Studies have shown that the fibrinolytic system can be activated in the invasive operation of IFF, which leads to massive blood loss during and after operation, especially hidden blood loss. Tranexamic acid, as an anti-fibrinolytic drug, can effectively reduce fibrinolytic activity by inhibiting fibrinolysis induced by fibrinolytic enzymes in order to stop bleeding. In recent years, with the diversified development of surgical hemostasis methods and the continuous exploration of hemostatic drugs, the application of anti-fibrinolytic drugs represented by tranexamic acid in perioperative period of IFF has gradually increased. Based on literatures at home and abroad, this paper aims to summarize the research progress of the application of tranexamic acid to reduce the perioperative hidden blood loss in intertrochanteric fracture, providing reference for clinical treatment decision. Key words: Tranexamic acid; Femoral fractures; Hidden blood loss