周细胞
血管生成
萌芽血管生成
血管生成
生物
神经科学
细胞生物学
功能(生物学)
壁细胞
新生血管
血管平滑肌
内皮干细胞
祖细胞
平滑肌
干细胞
癌症研究
遗传学
体外
内分泌学
作者
Laura Beth Payne,Maruf Hoque,Clifton Houk,Jordan Darden,John C. Chappell
标识
DOI:10.1007/s43152-020-00014-9
摘要
Pericytes are essential components of capillaries in many tissues and organs, contributing to vessel stability and integrity, with additional contributions to microvascular function still being discovered. We review current and foundational studies identifying pericyte differentiation mechanics and their roles in the earliest stages of vessel formation.Recent advances in pericyte-focused tools and models have illuminated critical aspects of pericyte biology including their roles in vascular development.Pericytes likely collaborate with endothelial cells undergoing vasculogenesis, initiating direct interactions during sprouting and intussusceptive angiogenesis. Pericytes also provide important regulation of vascular growth including mechanisms underlying vessel pruning, rarefaction, and subsequent regrowth.
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