共同伴侣
伴侣(临床)
蛋白质折叠
热休克蛋白70
计算生物学
细胞生物学
化学
折叠(DSP实现)
生物
热休克蛋白
生物化学
医学
工程类
基因
电气工程
病理
作者
Ofrah Faust,Rina Rosenzweig
标识
DOI:10.1007/978-3-030-40204-4_1
摘要
Hsp70s are ubiquitous molecular chaperones that act in a myriad of cellular functions, affecting virtually all aspects in the life of proteins from synthesis to degradation. Hsp70 proteins act in the cell in cooperation with a large set of dedicated co-chaperones consisting of J-domain proteins and nucleotide exchange factors that regulate the Hsp70 chaperone cycle. Recent studies have made significant progress towards obtaining a better understanding of the mechanisms through which Hsp70s and their co-chaperones operate, providing insights into structural, kinetic, and functional features of the various members of this network. In this chapter we describe the emerging working principles of the Hsp70 machine and its co-chaperones, and highlight how mechanistic aspects of this network are tied to distinct protein folding functions.
科研通智能强力驱动
Strongly Powered by AbleSci AI