化学
表面改性
亲核细胞
组合化学
达布科
胺气处理
亲核取代
小学(天文学)
有机化学
辛烷值
催化作用
物理化学
天文
物理
作者
Yuvraj B. Bhujabal,Kamlesh S. Vadagaonkar,Aniket Gholap,Yogesh S. Sanghvi,Rambabu Dandela,Anant R. Kapdi
标识
DOI:10.1021/acs.joc.9b02371
摘要
A highly efficient and an unprecedented hexafluoro-2-propanol, promoting low-temperature aromatic nucleophilic substitutions of chloroheteroarenes, has been performed using thiols and (secondary) amines under base-free and metal-free conditions. The developed protocol also provides excellent regio-control for the selective functionalization of dichloroheteroarenes, while the utility of the protocol was demonstrated by the modification of a commercially available drug ceritinib.
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