Effect of vitamin E in non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomised controlled trials

医学 贾达德量表 脂肪肝 内科学 荟萃分析 丙氨酸转氨酶 安慰剂 临床试验 天冬氨酸转氨酶 转氨酶 胃肠病学 维生素 肝功能 随机对照试验 疾病 病理 碱性磷酸酶 替代医学 科克伦图书馆 生物化学 化学
作者
Iram Amanullah,Yusra Habib Khan,Iqraa Anwar,Aqsa Gulzar,Tauqeer Hussain Mallhi,Raja Ahsan Aftab
出处
期刊:Postgraduate Medical Journal [Oxford University Press]
卷期号:95 (1129): 601-611 被引量:86
标识
DOI:10.1136/postgradmedj-2018-136364
摘要

Abstract The efficacy of vitamin E among patients with non-alcoholic fatty liver disease (NAFLD) is unclear. The current qualitative and quantitative analyses aimed to ascertain the efficacy of vitamin E on clinical outcomes of patients with NAFLD. A systematic search of randomised controlled trials (RCTs) was performed using databases (PubMed, ProQuest, Scopus, EBSCOhost and Ovid) from inception to July 2018. Trials meeting the inclusion criteria were subjected to quality assessment using the Jadad Scoring. All trials meeting the prerequisites information for meta-analysis were subjected to quantitative synthesis of results. Nine RCTs (five in adults and four in children) were included. Four of the five RCTs on adults demonstrated significant improvements in alanine transaminase and other liver function surrogates in patients with NAFLD. On the other hand, only one of the four RCTs conducted on children showed significant improvements in liver functions with the use of vitamin E. Although quantitative synthesis of available data revealed insignificant differences between vitamin E and placebo, still the use of vitamin E improves the level of alanine transaminase and aspartate transaminase by −1.96 and −0.59, with heterogeneity of I2=67% and I2=0%, respectively. Adjuvant vitamin E therapy provides significant biochemical and histological improvements in adult patients with NAFLD, while paediatric patients showed insignificant efficacy compared with placebo. Lifestyle interventions along with vitamin E can provide much better results. Data, including the impact of vitamin E on hepatic histology, are still lacking. Moreover, the short duration of trials limits the conclusion on the safety and efficacy of proposed treatments.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
无知小白完成签到,获得积分10
刚刚
moumou完成签到,获得积分10
1秒前
李钧鹏完成签到,获得积分10
1秒前
laber应助小诗人采纳,获得50
2秒前
有魅力的不评完成签到,获得积分10
2秒前
麋鹿发布了新的文献求助10
2秒前
4秒前
火星上含海完成签到,获得积分10
6秒前
小马甲应助张雯思采纳,获得10
10秒前
41应助张雯思采纳,获得10
10秒前
李健的粉丝团团长应助123采纳,获得10
10秒前
孙燕应助张雯思采纳,获得10
10秒前
打打应助张雯思采纳,获得10
10秒前
情怀应助张雯思采纳,获得10
10秒前
孙燕应助张雯思采纳,获得10
10秒前
Hello应助张雯思采纳,获得10
10秒前
搜集达人应助张雯思采纳,获得10
10秒前
赘婿应助张雯思采纳,获得10
10秒前
今后应助张雯思采纳,获得10
10秒前
量子星尘发布了新的文献求助10
11秒前
麋鹿完成签到,获得积分20
11秒前
赵子完成签到,获得积分10
14秒前
英姑应助会飞的鱼采纳,获得10
15秒前
18秒前
FashionBoy应助勤恳化蛹采纳,获得10
19秒前
21秒前
平淡小白菜完成签到,获得积分10
23秒前
lzx发布了新的文献求助10
24秒前
Jun发布了新的文献求助10
24秒前
隐形曼青应助搞怪的紫易采纳,获得10
25秒前
26秒前
xxddw发布了新的文献求助10
27秒前
大反应釜发布了新的文献求助20
31秒前
123发布了新的文献求助10
31秒前
hugeyoung完成签到,获得积分10
34秒前
34秒前
耳百完成签到,获得积分10
35秒前
37秒前
38秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989444
求助须知:如何正确求助?哪些是违规求助? 3531531
关于积分的说明 11254250
捐赠科研通 3270191
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174