蛋白质组
细胞器
化学
内在无序蛋白质
液态液体
生物物理学
生物
色谱法
生物化学
作者
Maarten C. Hardenberg,Attila K. Horváth,Viktor Ambrus,Monika Fuxreiter,Christopher M. Dobson
标识
DOI:10.1073/pnas.2007670117
摘要
Significance Liquid–liquid phase separation of proteins results in biomolecular condensates, which contribute to the organization of cellular matter into membraneless organelles. It is still unclear, however, whether these condensates represent a common state of proteins. Here, based on biophysical principles driving phase separation, we report a proteome-wide ranking of proteins according to their propensity to condensate into a droplet state. We analyze two mechanisms for droplet formation—driver proteins can spontaneously phase separate, while client proteins require additional components. We conclude that the droplet state, as the native and amyloid states, is a fundamental state of proteins, with most proteins expected to be capable of undergoing liquid–liquid phase separation via either of these two mechanisms.
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