细胞凋亡
胶质瘤
生物
标记法
下调和上调
细胞生长
癌症研究
核糖核酸
甲基化
分子生物学
细胞生物学
细胞
基因
遗传学
作者
Feng Li,Chao Zhang,Guifang Zhang
摘要
Glioma, as one of the most aggressive tumors, is hardly cleaned by surgical removal, leading to a low survival rate. m6A is an internal modification in RNA and plays an important role in many kinds of cancers. In our study, we detected that the m6A level was decreased in glioma tissue, which might be caused by decreased METTL3 and increased FTO levels. We upregulated the m6A level in U251 cells by overexpressing <i>METTL3</i>. The results showed that a high level of m6A led to a reduced migration and proliferation ability, and vice versa. Finally, we performed a TUNEL assay and showed that m6A regulated cell proliferation by influencing apoptosis of U251 cells through regulating <i>HSP90</i> expression.
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