[The intestinal microflora and cholestatic liver diseases].

Cholestatic liver diseases (CHD) refers to a kind of liver disease in which accumulation of excessive bile due to various causes from inside and outside of the liver blocks the formation, secretion and excretion of bile, and thereby induce the normal bile flow unable to enter the duodenum. During the occurrence and development of CHD, intestinal microflora plays an important role in regulating bile acid metabolism, and immune response. In addition, CHD affects the composition, abundance and function of intestinal microflora, which in turn affects the synthesis and metabolism of bile acids. Hence, bile acids being an important signaling molecule for the occurrence and development of CHD plays role in the pathophysiological processes through bile acid transporters and nuclear receptors, such as farnesoid receptors. This paper briefly introduces the relationship between intestinal microecology and cholestatic liver disease based on the interrelationship among bile acid, intestinal flora and cholestatic liver disease, with a view to provide assistance in the treatment of cholestatic liver disease.胆汁淤积性肝病是指肝内外各种原因造成胆汁形成、分泌、排泄障碍，胆汁流无法正常进入十二指肠，而在肝脏过度淤积的一类肝病。在胆汁淤积性肝病的发生和发展过程中，肠道微生物群通过调节新陈代谢、免疫反应和胆汁酸的代谢起着重要的作用。胆汁淤积性肝病也会影响肠道微生物群的构成、丰度及功能，反过来再影响胆汁酸的合成、代谢。胆汁酸是胆汁淤积性肝病发生和发展中的重要信号分子，通过对胆汁酸转运蛋白和核受体如法尼醇受体参与到胆汁淤积性肝病的病理学和生理学过程。现以胆汁酸、肠道菌群、胆汁淤积性肝病之间的相互联系为主线，简要介绍肠道微生态和胆汁淤积性肝病之间的关系，以期为胆汁淤积性肝病的治疗提供帮助。.