European experts consensus: BRCA/homologous recombination deficiency testing in first-line ovarian cancer

基因检测医学卵巢癌 BRCA突变同源重组肿瘤科妇科内科学癌症遗传学生物基因

作者

Ignace Vergote,Antonio González‐Martín,Isabelle Ray‐Coquard,Philipp Harter,Nicoletta Colombo,Pascal Pujol,Domenica Lorusso,Mansoor Raza Mirza,Birutė Brasiūnienė,Radosław Mądry,James D. Brenton,Margreet G.E.M. Ausems,Reinhard Büttner,Diether Lambrechts,Ignace Vergote,Margreet G.E.M. Ausems,Birutė Brasiūnienė,James D. Brenton,Reinhard Büttner,Nicoletta Colombo,Antonio González‐Martín,Philipp Harter,Diether Lambrechts,Domenica Lorusso,Radosław Mądry,Mansoor Raza Mirza,Pascal Pujol,Isabelle Ray‐Coquard,Mauro Henrique Nogueira Guimarães de Abreu,S. Balboni,Susana Banerjee,Massimo Barberis,M.P. Barretina Ginesta,J.F. Baurain,Margherita Bignami,Line Bjørge,Paweł Blecharz,Ilan Bruchim,ME Capilna,Nicoletta Cerana,Americo Cicchetti,Dearbhaile Catherine Collins,Nicole Concin,Maurizio D’Incalci,Brittany A. Davidson,Thibault De La Motte Rouge,Pierandrea De Iaco,Fuat Demirkıran,Hannelore Denys,Thilo Doerk,Anne Dørum,Annamaria Ferrero,Alejandro Perez Fidalgo,Maurizio Genuardi,Laurence Gladieff,Rosalind Glasspool,Christoph Grimm,Murat Gültekin,Eric Hahnen,Annette Hasenburg,Alinta Hegmane,Viola Heinzelmann,Estrid Høgdall,Ramūnas Janavičius,Sonata Jarmalaitė,Roshni Kalachand,Radka Kaneva,Saadettin Kılıçkap,Roman Kocián,D. Kolencik,Rebecca Kristeleit,Anna Kryzhanivska,Alexandra Léary,Birthe Lemley,Marjolijn J.L. Ligtenberg,José Antonio López‐Guerrero,Christopher J. Lord,E. Åvall‐Lundqvist,Johanna Mäenpäa,Sven Mahner,Frederik Marmé,Christian Marth,Iain A. McNeish,Sabine Merkelbach‐Bruse,Marian J.E. Mourits,Nicola Normanno,Ana Oaknin,Kristiina Ojamaa,C. Papdimitriou,F. Penault-Llorca,Anna Myriam Perrone,Sandro Pignata,Eli Pikarsky,Étienne Rouleau,María Jesús Rubio,Anna Sapino,Barbara Schmalfeldt,Jalid Sehouli,Roni Shapira,Karina Dahl Steffensen,Vladyslav Sukhin,John Syrios,Zoltán Szállási,Çağatay Taşkıran,Marija Terzic,Marc Tischkowitz,I. Toth,K. Van de Vijver,Mehmet Ali Vardar,Bartosz Wasąg,Pauline Wimberger,Els O. Witteveen

出处

期刊：Annals of Oncology [Elsevier]
日期：2021-12-01 卷期号：33 (3): 276-287 被引量：105

标识

DOI：10.1016/j.annonc.2021.11.013

摘要

Homologous recombination repair (HRR) enables fault-free repair of double-stranded DNA breaks. HRR deficiency is predicted to occur in around half of high-grade serous ovarian carcinomas. Ovarian cancers harbouring HRR deficiency typically exhibit sensitivity to poly-ADP ribose polymerase inhibitors (PARPi). Current guidelines recommend a range of approaches for genetic testing to identify predictors of sensitivity to PARPi in ovarian cancer and to identify genetic predisposition.

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European experts consensus: BRCA/homologous recombination deficiency testing in first-line ovarian cancer

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