动力学分辨率
试剂
对映选择合成
绝对构型
化学
组合化学
全合成
吡啶
模块化设计
催化作用
立体化学
有机化学
计算机科学
操作系统
作者
Renzo Alexander Samame
摘要
The first part of this thesis illustrates the application of kinetic resolution reagents for the determination of absolute configuration. A dual-catalytic approach based on ion pair recognition was explored using the combined action of 4-(N,N-dimethylamino)pyridine (DMAP) and a chiral thiourea receptor co-catalyst. After difficulties were encountered with a dual-catalytic mode, an alternative approach using enantioselective acyl transfer reagents was investigated. The new strategy led to a successful development of a new and efficient method to rapidly establish the absolute configuration of primary amines using mass spectrometry. Part two of this thesis describes the development of a modular approach toward the synthesis of the Lycopodium alkaloids. A highly concise six-step total synthesis of the complex alkaloid (+)-fastigiatine was accomplished using a transannular Mannich reaction that generated two quaternary carbons at a late stage. The modular approach to fastigiatine will be expanded to other members of the family including himeradine A and lyconadin A.
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