半乳甘露聚糖
支气管肺泡灌洗
医学
曲菌病
曲霉
胃肠病学
内科学
肺曲菌病
病理
肺
免疫学
微生物学
生物
作者
Hadir A. El-Mahallawy,Rana El-Gendi,Doaa Ghaith,Iman Kamal Behiry,Soheir Fathy Helal
出处
期刊:Open Access Macedonian Journal of Medical Sciences
[ID Design 2012/DOOEL Skopje]
日期:2021-06-02
卷期号:9 (A): 362-366
标识
DOI:10.3889/oamjms.2021.5994
摘要
BACKGROUND: Serum 1, 3-β-D-glucan (BDG) assay was recommended for diagnosing fungal infections. AIM: We aimed to assess 1, 3-β-D-glucan in bronchoalveolar lavage (BAL) fluid in invasive pulmonary aspergillosis (IPA). METHODS: Out of 104 patients clinically suspected fungal, 45 were probable, 18 possible, and 41 unlikely according to EORTC/MSG 2008 criteria. Measuring BAL BDG and galactomannan were done. RESULTS: The sensitivity, specificity, and positive and negative predictive values (PPV and NPV) for BDG were 44%, 71%, 62%, and 54%; for galactomannan 84%, 83%, 84%, and 83%; and 93%, 66%, 75%, and 90%, respectively, when combining both tests. A significant different performance of GM; p = 0.0008 was detected in patients with malignant disorders when compared to non-malignant; but not for BDG; p = 0.121. CONCLUSION: We can conclude that BAL-BDG is helpful if positive in a clinically suspected IFI case, but if negative cannot rule out fungal infection. Thus, combining results of BAL-GM and BAL-BDG are recommended.
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