Applications of zeolitic imidazolate framework-8 (ZIF-8) in bone tissue engineering: A review

Bone tissue is a highly vascularized and dynamic tissue that continues to remodel throughout the life cycle of a person. Only a few researches are done on usage of zeolitic imidazolate framework-8 (ZIF-8) in the bone tissue engineering area. Hence, this review is focused on the application of the ZIF-8 in bone tissue engineering. This work includes an explanation of metal-organic frameworks (MOFs) and ZIF-8 including synthesis methods as well as biocompatibility and biomedical applications of ZIF-8. In fact, a literature review is provided on previous applications of ZIF-8 in bone tissue engineering. Also, the investigations related to employing ZIF-8 in bone scaffolds and drug delivery systems for the bone tissues are discussed, and future perspectives are also emphasized.