胰岛素释放
医学
胰岛素
纳米技术
食品药品监督管理局
临床试验
风险分析(工程)
计算机科学
糖尿病治疗
糖尿病
药物输送
重症监护医学
生化工程
1型糖尿病
2型糖尿病
材料科学
工程类
内科学
内分泌学
作者
Qida Zong,Ranran Guo,Naijun Dong,Guixia Ling,Peng Zhang
标识
DOI:10.1007/s13346-021-00981-y
摘要
As a painless and minimally invasive method of self-administration, microneedle is very promising to replace subcutaneous injection of insulin for type I diabetes treatment. Since the introduction of microneedles, many scholars have paid attention to and studied this technology, which has made it developed rapidly. However, there is no product on the market or in clinical trials at present. The reason is that there are still many technical problems in microneedle drug delivery system, such as the perfect integration of stable, controllable, fast, long-lasting, safe, and other necessary conditions. Here, we review the achievements that researchers have made that contain one or more of the above factors, and put some ideas to solve the limitations of insulin delivery by microneedles for reference.
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