嵌合抗原受体
抗原
癌症研究
卵巢癌
癌症
医学
T细胞
免疫学
生物
免疫系统
内科学
作者
Axel Hyrenius‐Wittsten,Su Yang,Minhee Park,Julie Garcia,Josef Alavi,Nathaniel Perry,Garrett Montgomery,Bin Liu,Kole T. Roybal
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2021-04-28
卷期号:13 (591)
被引量:145
标识
DOI:10.1126/scitranslmed.abd8836
摘要
SynNotch CAR circuits targeting specific solid tumor antigens enhance specificity and improve therapeutic efficacy by regulating T cell exhaustion.
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