白杨素
安普克
胰岛素抵抗
脂质代谢
化学
PI3K/AKT/mTOR通路
内分泌学
碳水化合物代谢
蛋白激酶B
内科学
糖代谢紊乱
胰岛素
生物化学
抗氧化剂
生物
信号转导
磷酸化
蛋白激酶A
医学
类黄酮
作者
Yingjun Zhou,Nuo Xu,Xiao‐Chen Zhang,Yuyan Zhu,Shaowei Liu,Yaning Chang
标识
DOI:10.1021/acs.jafc.1c01109
摘要
Natural products with minor side effects have been reported to be an effective adjuvant therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has a wide range of physiological effects, such as antioxidant, anti-inflammatory, anti-diabetes, anti-hyperlipidemia, and hepatoprotective. This study was designed to explore the effects and mechanism of chrysin on metabolic syndrome using insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice. The results indicated that chrysin significantly decreased insulin resistance, oxidative stress, inflammation, and liver injury. In addition, chrysin improved glycogen synthesis and fatty acid oxidation and inhibited gluconeogenesis and fatty acid synthesis by regulating GSK3β, G6Paes, PEPCK, SREBP1, FAS, and ACC1. Furthermore, the results of western blot and real-time PCR experiments demonstrated that chrysin modulated glucose and lipid metabolism through the AMPK/PI3K/AKT signaling pathway. Treatment with the AMPK inhibitor verified that AMPK activation is positively correlated with chrysin activity on glycolipid metabolism. This study confirms that chrysin is a potential treatment for glucose and lipid metabolism disorders.
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