微泡
血管生成
小RNA
癌症
癌症研究
环状RNA
核糖核酸
细胞质
生物
细胞生物学
化学
基因
生物化学
遗传学
作者
Shuang Li,Jia Li,Haiyang Zhang,Yan Zhang,Xinyi Wang,Haiou Yang,Zhengyang Zhou,Xishan Hao,Guoguang Ying,Yi Ba
标识
DOI:10.1016/j.bbrc.2021.04.099
摘要
Accumulating evidence has been found that circular RNA (circRNA) plays a critical role in the initiation and development of various diseases by modulating gene expression in the cytoplasm. However, the role of circ_0044366 (termed circ29) in gastric cancer (GC) has yet to be elusive. We detected that exosomal circ29 was confirmed to be highly expressed in GC and can significantly impair the proliferation, migration, tube formation of HUVEC by exosomal communication. Interestingly, this effect could be blocked by the effect of miR-29a. In brief, we confirmed that circ29, as a sponge of miR-29a, plays a responsible role in the occurrence and development of GC by regulating the VEGF pathway. Therefore, it may be used as a potential target for the treatment of GC.
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