三阴性乳腺癌
癌症研究
乳腺癌
细胞凋亡
脂质体
间隙
癌症
程序性细胞死亡
蒽醌
医学
药理学
化学
内科学
生物化学
泌尿科
有机化学
作者
Thomashire A. George,Max M. Chen,Andreas Czosseck,Hsiang-Pei Chen,Hsu‐Shan Huang,David J. Lundy
标识
DOI:10.1016/j.jconrel.2021.12.001
摘要
Breast cancer is the most common cancer among women and a leading cause of death worldwide. Triple negative breast cancer (TNBC) is a highly aggressive subtype which is the most challenging to treat. Due to heterogeneity and a lack of specific molecular targets, small molecule-based chemotherapy is the preferred course of treatment. However, these drugs have high toxicity due to off-target effects on healthy tissues, and tumors may develop resistance. Here, we present a polyethylene glycol-modified nanoscale liposomal formulation (LipoRV) of a new anthraquinone derivative which has potent effects on multiple TNBC cell lines. LipoRV readily inhibited the cell cycle, induced cell apoptosis, and reduced long-term proliferative potential of TNBC cells. In a xenograft animal model, LipoRV successfully cleared tumors and demonstrated a good safety profile, without detrimental effects on biochemical markers. Finally, RNA sequencing of LipoRV-treated TNBC cells was carried out, indicating that LipoRV may have immunomodulatory properties. These findings demonstrate that a liposomal anthraquinone-based molecule has excellent promise for TNBC therapy in the future.
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