三阴性乳腺癌
乳腺癌
生物标志物
癌症
转移
癌症研究
基因表达
肿瘤科
基因表达谱
医学
生物
内科学
基因
遗传学
标识
DOI:10.31219/osf.io/2grs7
摘要
We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of regulating synaptic membrane exocytosis 2, encoded by RIMS2 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, RIMS2 expression was significantly correlated with distant metastasis-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. RIMS2 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
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