Automated Dual-energy Computed Tomography-based Extracellular Volume Estimation for Myocardial Characterization in Patients With Ischemic and Nonischemic Cardiomyopathy

医学 计算机断层摄影术 心肌病 细胞外液 缺血性心肌病 核医学 心脏病学 放射科 双重能量 断层摄影术 内科学 细胞外 心力衰竭 射血分数 细胞生物学 生物 骨质疏松症 骨矿物
作者
Andres F. Abadia,Gilberto J. Aquino,U. Joseph Schoepf,Michael Wels,Bernhard Schmidt,Pooyan Sahbaee,Danielle M. Dargis,Jeremy R. Burt,Ákos Varga‐Szemes,Tilman Emrich
出处
期刊:Journal of Thoracic Imaging [Lippincott Williams & Wilkins]
卷期号:37 (5): 307-314 被引量:7
标识
DOI:10.1097/rti.0000000000000656
摘要

Objectives: We aimed to validate and test a prototype algorithm for automated dual-energy computed tomography (DECT)-based myocardial extracellular volume (ECV) assessment in patients with various cardiomyopathies. Methods: This retrospective study included healthy subjects (n=9; 61±10 y) and patients with cardiomyopathy (n=109, including a validation cohort n=60; 68±9 y; and a test cohort n=49; 69±11 y), who had previously undergone cardiac DECT. Myocardial ECV was calculated using a prototype-based fully automated algorithm and compared with manual assessment. Receiver-operating characteristic analysis was performed to test the algorithm’s ability to distinguish healthy subjects and patients with cardiomyopathy. Results: The fully automated method led to a significant reduction of postprocessing time compared with manual assessment (2.2±0.4 min and 9.4±0.7 min, respectively, P <0.001). There was no significant difference in ECV between the automated and manual methods ( P =0.088). The automated method showed moderate correlation and agreement with the manual technique ( r =0.68, intraclass correlation coefficient=0.66). ECV was significantly higher in patients with cardiomyopathy compared with healthy subjects, regardless of the method used ( P <0.001). In the test cohort, the automated method yielded an area under the curve of 0.98 for identifying patients with cardiomyopathies. Conclusion: Automated ECV estimation based on DECT showed moderate agreement with the manual method and matched with previously reported ECV values for healthy volunteers and patients with cardiomyopathy. The automatically derived ECV demonstrated an excellent diagnostic performance to discriminate between healthy and diseased myocardium, suggesting that it could be an effective initial screening tool while significantly reducing the time of assessment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
2秒前
Russell发布了新的文献求助10
2秒前
受伤幻桃发布了新的文献求助10
3秒前
大意的晓亦完成签到 ,获得积分10
4秒前
宁阿霜发布了新的文献求助10
5秒前
思源应助吉吉采纳,获得10
5秒前
怪物发布了新的文献求助10
6秒前
李大帅完成签到,获得积分10
6秒前
扬帆发布了新的文献求助10
8秒前
小蘑菇应助宫冷雁采纳,获得10
8秒前
量子星尘发布了新的文献求助150
8秒前
YY完成签到,获得积分10
9秒前
11秒前
慕青应助科研爱好者采纳,获得10
12秒前
pcr163应助粥游天下采纳,获得70
12秒前
13秒前
搜集达人应助乐观思萱采纳,获得10
13秒前
高贵的路灯完成签到,获得积分10
13秒前
March应助JingP采纳,获得10
14秒前
小桔子发布了新的文献求助10
17秒前
阿童木发布了新的文献求助10
18秒前
小小完成签到,获得积分10
19秒前
FashionBoy应助火火采纳,获得10
19秒前
BINGBING发布了新的文献求助10
20秒前
爆米花应助龙龍泷采纳,获得10
23秒前
李建勋完成签到,获得积分10
24秒前
26秒前
共享精神应助坚果采纳,获得10
26秒前
耍酷背包完成签到,获得积分20
28秒前
小桔子完成签到,获得积分20
29秒前
zhangwj226发布了新的文献求助10
30秒前
31秒前
31秒前
柏小霜完成签到 ,获得积分0
31秒前
FashionBoy应助耍酷背包采纳,获得30
31秒前
123完成签到,获得积分10
32秒前
111发布了新的文献求助10
32秒前
33秒前
Alex给冷酷的若剑的求助进行了留言
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971424
求助须知:如何正确求助?哪些是违规求助? 3516157
关于积分的说明 11181063
捐赠科研通 3251297
什么是DOI,文献DOI怎么找? 1795776
邀请新用户注册赠送积分活动 876012
科研通“疑难数据库(出版商)”最低求助积分说明 805228