Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors

Sirtuin belongs to a family of coenzyme nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, which could be classified as seven isoforms (SIRT1-SIRT7). Recently, SIRT5 has drawn extensive attention due to its specific catalytic activity for low deacetylation activity but significant desuccinylation, demalonylation and deglutarylation activities. SIRT5 is thought to be closely related to some diseases such as cancer and neurodegenerative diseases. Herein, we present an overview of the structure and biological function of SIRT5 as well as the advances in SIRT5 inhibitors research. We also provide insights for the future exploitation of SIRT5 inhibitors.