已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Oscillometry and Asthma Control in Patients With and Without Fixed Airflow Obstruction

肺活量测定 哮喘 医学 支气管扩张剂 肺功能测试 内科学 心脏病学 物理疗法
作者
Alice M. Cottee,Leigh M. Seccombe,Cindy Thamrin,Gregory G. King,Matthew Peters,Claude S. Farah
出处
期刊:The Journal of Allergy and Clinical Immunology: In Practice [Elsevier BV]
卷期号:10 (5): 1260-1267.e1 被引量:12
标识
DOI:10.1016/j.jaip.2021.12.026
摘要

Asthma is defined by the presence of reversible airflow limitation, yet persistently abnormal spirometry may develop despite appropriate asthma treatment. Fixed airflow obstruction (FAO) describes abnormal postbronchodilator spirometry that is associated with greater symptom burden and disease severity. Respiratory oscillometry measures the mechanics of the entire airway tree, including peripheral airway changes that have been shown to influence asthma symptoms.To evaluate the relationship between abnormal oscillometry following bronchodilator and symptom control in adults with asthma.A prospective cohort of patients with asthma attending an airways clinic completed oscillometry (resistance and reactance), spirometry, and the Asthma Control Test. Postbronchodilator lung function below the lower limit of normal was considered abnormal. Spirometric FAO was defined as FEV1/forced vital capacity below the lower limit of normal. Spearman's rank coefficient and multiple linear regression were performed to assess associations of lung function parameters with Asthma Control Test. The discriminative ability of abnormal lung function to identify poor asthma control was determined using Cohen's kappa.Ninety patients with asthma were included; 48% had spirometric FAO. Only reactance parameters, not spirometry, significantly related to (rs ≥ 0.315; P < .05) and identified asthma control (r2 = 0.236; P < .001). Lung function was more strongly associated with asthma control in patients with FAO compared with those without. Abnormal oscillometry identified an additional 24% of patients with poor asthma control as compared with spirometric FAO.Reactance related to asthma control, independently of spirometric FAO. Abnormal postbronchodilator reactance identified more patients with poor asthma control compared with spirometry. These findings confirm that oscillometry is a relevant lung function test in the clinical assessment of asthma.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
2秒前
AFM发布了新的文献求助10
7秒前
8秒前
独特跳跳糖完成签到 ,获得积分10
8秒前
立军完成签到,获得积分10
11秒前
Sarah完成签到 ,获得积分10
12秒前
落晖完成签到 ,获得积分10
12秒前
Chi_bio发布了新的文献求助10
12秒前
xx1234567890发布了新的文献求助10
13秒前
张aa完成签到 ,获得积分10
13秒前
风鱼完成签到 ,获得积分10
14秒前
没有昵称完成签到 ,获得积分10
17秒前
三井库里发布了新的文献求助10
19秒前
23秒前
洛芷发布了新的文献求助10
26秒前
在水一方应助hugeng采纳,获得10
26秒前
Eliauk完成签到 ,获得积分10
28秒前
Jepsen完成签到 ,获得积分10
28秒前
28秒前
hhhi发布了新的文献求助10
33秒前
空里流霜不觉飞完成签到 ,获得积分10
34秒前
37秒前
hugeng完成签到,获得积分10
38秒前
noothinh完成签到,获得积分10
39秒前
Chi_bio完成签到,获得积分10
40秒前
lizigongzhu完成签到,获得积分10
40秒前
hugeng发布了新的文献求助10
41秒前
ding应助昏睡的南霜采纳,获得10
42秒前
ding应助曹大壮采纳,获得10
42秒前
yydragen应助黎乐荷采纳,获得30
42秒前
42秒前
Lucas应助废式脂肪采纳,获得10
43秒前
46秒前
lizigongzhu发布了新的文献求助10
49秒前
三井库里发布了新的文献求助10
51秒前
念初发布了新的文献求助10
52秒前
桐桐应助水之冬采纳,获得10
53秒前
54秒前
废式脂肪发布了新的文献求助10
57秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989918
求助须知:如何正确求助?哪些是违规求助? 3532013
关于积分的说明 11255831
捐赠科研通 3270829
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882233
科研通“疑难数据库(出版商)”最低求助积分说明 809216